PredictCan Biotechnologies
“PredictCan Biotechnologies has patented cell education technology that exploits the intrinsic plasticity of cell lines by inducing subject-dependent phenotypic changes to better model cohorts of healthy or pathological individuals with tailored characteristics. The company generates state-of-the-art 3D individual-centric models for early detection of cancers, drug discovery, drug safety, and drug efficacy. Among our models, GenuineSelect-TOX is a platform that accurately detects intrinsic DILI and immune-mediated idiosyncratic DILI (iDILI) during the early and late stages of drug development.
Exir Bio
Exir Bio’s goal is to accelerate drug discovery, efficacy, and safety assessments by combining nonhuman primate (NHP) in vitro / in vivo models,
replacing, reducing, and refining (3R’s) the use of NHPs – necessary due to the global shortage of NHPs and in accordance with US Modernization Act
2.0.
Exir Bio has access to ~20,000 NHP’s / 8 species across several colonies in the US, all with known origin and bred in captivity per FDA and European
Union requirements.
STEMCELL Technologies
We are the world-leading provider of reagents and services for generating organoid and stem cell-derived models of healthy and diseased human tissues.
AnaBios
AnaBios aims to establish the safety and efficacy of novel compounds through its advanced, human-focused translational technologies, including superior quality human tissue samples and functional assays focused, as well as human primary cells through its subsidiary Cell Systems.
Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model
This study assesses the developmental neurotoxicity of paroxetine—a widely used SSRI which has shown contradictory evidence regarding effects on human brain development using a versatile, organotypic human induced pluripotent stem cell (iPSC)-derived brain model (BrainSpheres).
A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System
This work presents a new and reproducible alveolar in vitro model, that combines a human derived immortalized alveolar epithelial cell line (AXiAEC) and organ-on-chip technology mimicking the lung alveolar biophysical environment to study inhalation toxicity, test safety and efficacy of drug compounds.
Ncardia
For more than a decade, Ncardia has been pioneering innovations in human induced pluripotent stem cells (iPSC).
NETRI
NETRI is an industrial start-up developing innovative technologies for the pharmaceutical industry. Its patented organs-on-chip technologies allow the creation of standardized and predictive human in vitro models.
React4Life
React4Life provides MIVO® organ-on-chip technology for advanced in vitro testing. Our platform can closely replicate human physiology by hosting 3D human cells or clinically relevant sized tissues under precisely controlled fluid dynamic conditions. Our multi-organ configuration enables simultaneous investigations into drug efficacy and cytotoxic effects, providing a more comprehensive and relevant context.