Microphysiological Systems Initiative
FAQ & How To Join

The 3Rs Collaborative’s MPS Initiative is the premier expert working group for stakeholders across the industry – but especially commercial developers – working to advance the adoption and acceptance of MPS. Below are frequently asked questions about our initiative as well as information about how to join.

The 3RC MPS Initiative is an industry group of MPS professionals and end-users that strives to increase the adoption of MPS technologies through stakeholder engagement. To learn more about our group, visit our website and view our charter.

Our initiative is comprised primarily of developers of commercially available MPS technologies. In fact, we have over 28 unique technology providers in our group already. Additionally, we include enabling technology providers and end-users to participate in the group. We work across North America and Europe to increase our impact and recognize the global nature of the field. 

Beyond group membership, our MPS initiative exists in a wider organization that recognizes the value and necessity of animal research. 3RsC is a non-profit dedicated to the advancement of all 3Rs of animal research: refinement, reduction & replacement. 

  • Commercial members are featured in our MPS technology hub alongside 30+ other top MPS providers. This hub was designed to assist end-users in their decision of which company(s) to engage with
  • Ability to present at quarterly data-driven virtual webinars that are directly advertised to members of the IQ-MPS (pharma MPS group) and FDA-CDER due to our formal partnerships with each group
  • Ability to contribute to projects to advance regulatory acceptance of MPS via the 3RsC’s Consortium agreement with the FDA-CDER (current project is primarily focused on DILI)
  • Membership pin and flyer to display at conferences noting your membership.
  • Contribute to cross-platform thought leadership and expert consensus documents.
  • Networking and collaboration with key MPS subject matter experts
  • Logo featured in 3RsC MPS presentations and website.
  • Demonstrate your broad support for the 3Rs.

Generally, membership is restricted to commercially available technology providers of MPS systems, MPSenabling technology providers (who have a core mission focused on MPS), MPS end-users, MPS regulatory members, MPS consultants, etc. 

Commercial developers must meet the below criteria for inclusion in the technology hub:

  • Commercially available MPS (ready to sell)
  • Products/Services available in North America/Europe
  • Reference from a Current Member of the 3RsC or Reputable End-User
  • Legally formed Entity
  • Website in English

As of 2023, it is required for institutions to contribute a minimum of $1000 per institution per year per paid 3RsC initiative. An institution is welcome to have multiple members join. This fee covers inclusion in our Technology Hub for providers. It also covers all the project management aspects of the initiative. 

Some institutions choose to become a higher-level member of the 3RsC to help support our wider mission of advancing better science – for both people and animals and gain additional visibility. Find out more about general membership by clicking here. 


We expect an active contribution from at least one member per institution to the various outputs of our initiative. At minimum, we requires a timely response to email requests for key information about your company and opinions on consensus documents. Additionally, we host at least one meeting a quarter (currently on third Thursdays at 12pm EST) and a few hours of additional work a month. Tasks may include providing info for the tech hub, responding to email requests, contributing to our context of use document, etc.  

However, we also recognize that there are phases of the year where you may be able to be more or less active. We don’t expect a continuously high contribution (although it is appreciated). Some of our companies may contribute more for a few months and then less for another few. We also allow companies to have multiple members representing them in the group and so these contributions can be rotated/spread across several individuals in one institution.  

  1. Complete our 3RsC-MPS Initiative Membership Application
  2. Your application will be passed along to our staff and membership committee who will evaluate you for our minimum requirements.
    • All members: Clear personal/institutional focus on MPS
    • Commercial Members:
      • Commercially available MPS (ready to sell) or technology/equipment that enables the use of MPS
      • Products/Services available in North America/Europe
      • Legally formed Entity
      • Website in English
  3. If approved, you will be sent an invoice to pay the membership fee.
  4. Once paid, you will be on-boarded to our initiative.

Once your invoice is paid, our staff will reach out to confirm what members of your company want to be involved in our group and which subgroups they’d like to be a part of. We will send those individuals meeting invitations, an invitation to our MS Teams working space, and add them to our contact list. We will add your company logo to our initiative member list.  Finally, we will share our formal membership expectations, MOU with the IQ-MPS, and communication guidelines. 

See Next

MPS Conferences