BiomimX
09/21/2021
A dynamic microscale mid-throughput fibrosis model to investigate the effects of different ratios of cardiomyocytes and fibroblasts |
Microphysiological Systems (MPS) are in vitro models composed of cells, tissue explants, or stem-cell derived ‘organoid’ formations of human or animal origin. These models provide translational biochemical, electrical, and/or physiomechanical responses to represent organ and tissue function, with great potential to replace some animals used in research.
Below you can explore publications from Microphysiological System Companies offering commercially available advanced in vitro models. This publication page has last been updated in December 2023.
To learn more about a particular organ system or disease area, you can filter publications by the filters below.
A dynamic microscale mid-throughput fibrosis model to investigate the effects of different ratios of cardiomyocytes and fibroblasts |
A functional precision medicine pipeline combines comparative transcriptomics and tumor organoid modeling to identify bespoke treatment strategies for glioblastoma |
A Human Brain-Chip for Modeling Brain Pathologies and Screening Blood–Brain Barrier Crossing Therapeutic Strategies |
A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture |
This study assesses the developmental neurotoxicity of paroxetine—a widely used SSRI which has shown contradictory evidence regarding effects on human brain development using a versatile, organotypic human induced pluripotent stem cell (iPSC)-derived brain model (BrainSpheres).
Assessment of Drug-Induced Toxicity Biomarkers in the Brain Microphysiological System (MPS) Using Targeted and Untargeted Molecular Profiling |
Ceramic additive manufacturing and microstructural analysis of tricalcium phosphate implants using X-ray microcomputed tomography |
Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism |
Evaluating the Anticancer Activity of Natural Products Using a Novel 3D Culture Model. |
High content analysis of in vitro alveolar macrophage responses can provide mechanistic insight for inhaled product safety assessment |
Inhibition of Metalloproteinases Extends Longevity and Function of In Vitro Human iPSC-Derived Skeletal Muscle |
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro |
Modeling chemotherapy-induced peripheral neuropathy using a nerve-on-a-chip microphysiological system |
Modeling Neurodegenerative Diseases Using In Vitro Compartmentalized Microfluidic Devices |
This publication presents a 3D in vitro model of human bone marrow that contains both the perivascular and endosteal niches, complete with dynamic, perfusable vascular networks to replicate in vivo bone marrow function, including maintenance and differentiation.
Tumor Microenvironment and Hydrogel-Based 3D Cancer Models for In Vitro Testing Immunotherapies |
Versican secreted by the ovary links ovulation and migration in fallopian tube derived serous cancer |