Microphysiological Systems (MPS) are a promising technology that can contribute to the refinement, reduction, and replacement of animals in research. MPS are miniaturized systems that mimic either a healthy or diseased physiology of tissues, organs, or organ systems. They contain major organ specific cell types arranged as in organs to allow for cell-cell interactions. We consider MPS to include complex in vitro models such as spheroids, organoids, and organ-on-a-chip technology.

MPS are an incredible technology that allow scientists to ask and answer important research questions. This technology is especially promising for use in early discovery research, to fill gaps with animal models, and in an integrated framework with animal research. 

The 3RsC-MPS Initiative is the premier expert working group of MPS stakeholders across the industry – but especially commercial developers – that works together to increase the adoption and acceptance of MPS technologies. Our initiative focuses on engaging with end-users, maintaining a user-friendly technology hub, and advancing regulatory use of MPS. Click here to learn about our initiative in depth and how to join.

Check out the different pages liked above to learn more and click the image below to view the slides from the 2024 MPS World Summit to learn more about our work thus far, impacts, and upcoming projects.