Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model
This study assesses the developmental neurotoxicity of paroxetine—a widely used SSRI which has shown contradictory evidence regarding effects on human brain development using a versatile, organotypic human induced pluripotent stem cell (iPSC)-derived brain model (BrainSpheres).
A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System
This work presents a new and reproducible alveolar in vitro model, that combines a human derived immortalized alveolar epithelial cell line (AXiAEC) and organ-on-chip technology mimicking the lung alveolar biophysical environment to study inhalation toxicity, test safety and efficacy of drug compounds.
Ncardia
For more than a decade, Ncardia has been pioneering innovations in human induced pluripotent stem cells (iPSC).
NETRI
NETRI is an industrial start-up developing innovative technologies for the pharmaceutical industry. Its patented organs-on-chip technologies allow the creation of standardized and predictive human in vitro models.
React4Life
React4Life provides MIVO® organ-on-chip technology for advanced in vitro testing. Our platform can closely replicate human physiology by hosting 3D human cells or clinically relevant sized tissues under precisely controlled fluid dynamic conditions. Our multi-organ configuration enables simultaneous investigations into drug efficacy and cytotoxic effects, providing a more comprehensive and relevant context.
BiomimX
BiomimX develops the next generation of beating organs-on-chips. uBeat® Platforms and connected hardware provide 3D miniaturized constructs with a tunable mechanical stimulation to model human organs’ function and diseases. uBeat® products and customized drug screening services are available.
Newcells Biotech
Newcells Biotech uses 3D in vitro modelling expertise to develop nephrotoxicity and renal transporter assays that most accurately predict in vivo outcomes, as well as producing fully developed hiPSC-derived Retinal Organoids.
Alcyomics
Alcyomics is a pre-clinical service provider using Skimune®, non-artificial human skin explants to predict adverse immune reactions of novel compounds. The Skimune® platform also assess the efficacy of monoclonal antibodies, immune inhibitors and safety of cellular therapies.
AlveoliX
AlveoliX is a Swiss-based organ-on-chip company. Our product is comprised of different hardware components and the easy-to-handle organ-on-chip consumable AX12. On the AX12 healthy and diseased biomodels can be created to study drug safety and efficacy and to answer fundamental research questions.